! ! This file is automatically generated with ! the System Biology Format Converter (http://sbfc.sourceforge.net/) ! from an SBML file. ! ! ! Model name = SABIOmdl28Apr2024117 ! ! Model ! FunctionDefinition id = KL_39851 !KL_39851(Km)=(NaN)! lambda(Km, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(Km, NaN) ! FunctionDefinition id = KL_39850 !KL_39850(Km)=(NaN)! lambda(Km, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(Km, NaN) ! FunctionDefinition id = KL_48160 !KL_48160(A,IC_50)=(NaN)! lambda(A, IC_50, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(A, IC_50, NaN) ! FunctionDefinition id = KL_48161 !KL_48161(IC_50,A)=(NaN)! lambda(IC_50, A, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(IC_50, A, NaN) ! FunctionDefinition id = KL_48158 !KL_48158(Km,Vmax,A)=(Vmax*A/(Km+A))! lambda(Km, Vmax, A, Vmax*A/(Km+A)) ! FunctionDefinition id = KL_48159 !KL_48159(Km,Vmax,A)=(Vmax*A/(Km+A))! lambda(Km, Vmax, A, Vmax*A/(Km+A)) ! FunctionDefinition id = KL_21313 !KL_21313(Km,S,Vmax)=(Vmax*S/(Km+S))! lambda(Km, S, Vmax, Vmax*S/(Km+S)) ! FunctionDefinition id = KL_21319 !KL_21319(S,EA)=(NaN)! lambda(S, EA, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(S, EA, NaN) ! FunctionDefinition id = KL_21316 !KL_21316(S,EA)=(NaN)! lambda(S, EA, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(S, EA, NaN) ! FunctionDefinition id = KL_21321 !KL_21321(EA,S)=(NaN)! lambda(EA, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(EA, S, NaN) ! FunctionDefinition id = KL_21314 !KL_21314(S,EA)=(NaN)! lambda(S, EA, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(S, EA, NaN) ! FunctionDefinition id = KL_21317 !KL_21317(EA,S)=(NaN)! lambda(EA, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(EA, S, NaN) ! FunctionDefinition id = KL_21315 !KL_21315(EA,S)=(NaN)! lambda(EA, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(EA, S, NaN) ! FunctionDefinition id = KL_21318 !KL_21318(EA,S)=(NaN)! lambda(EA, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(EA, S, NaN) ! FunctionDefinition id = KL_21320 !KL_21320(EA,S)=(NaN)! lambda(EA, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(EA, S, NaN) ! FunctionDefinition id = KL_50493 !KL_50493(Vmax,S,Km)=(Vmax*S/(S+Km))! lambda(Vmax, S, Km, Vmax*S/(S+Km)) ! FunctionDefinition id = KL_41756 !KL_41756(Ki,A,S)=(NaN)! lambda(Ki, A, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(Ki, A, S, NaN) ! FunctionDefinition id = KL_41757 !KL_41757(Ki,A,S)=(NaN)! lambda(Ki, A, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(Ki, A, S, NaN) ! FunctionDefinition id = KL_41754 !KL_41754(S,A,Ki)=(NaN)! lambda(S, A, Ki, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(S, A, Ki, NaN) ! FunctionDefinition id = KL_41755 !KL_41755(A,Ki,S)=(NaN)! lambda(A, Ki, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(A, Ki, S, NaN) ! FunctionDefinition id = KL_41750 !KL_41750(Km,A,Vmax,S)=(Vmax*S/(Km+S))! lambda(Km, A, Vmax, S, Vmax*S/(Km+S)) ! FunctionDefinition id = KL_41752 !KL_41752(S,A,Km,Vmax)=(Vmax*S/(Km+S))! lambda(S, A, Km, Vmax, Vmax*S/(Km+S)) ! FunctionDefinition id = KL_41751 !KL_41751(S,Vmax,Km,A)=(Vmax*S/(Km+S))! lambda(S, Vmax, Km, A, Vmax*S/(Km+S)) ! FunctionDefinition id = KL_41749 !KL_41749(n,Vmax_Km,Km2,Km1,A,Vmax)=(NaN)! lambda(n, Vmax_Km, Km2, Km1, A, Vmax, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(n, Vmax_Km, Km2, Km1, A, Vmax, NaN) ! FunctionDefinition id = KL_41753 !KL_41753(S,Vmax,Km,A)=(Vmax*S/(Km+S))! lambda(S, Vmax, Km, A, Vmax*S/(Km+S)) ! FunctionDefinition id = KL_41768 !KL_41768(I,Ki,S,n,A)=(NaN)! lambda(I, Ki, S, n, A, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(I, Ki, S, n, A, NaN) ! FunctionDefinition id = KL_41767 !KL_41767(Ki,S,A)=(NaN)! lambda(Ki, S, A, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(Ki, S, A, NaN) ! FunctionDefinition id = KL_41745 !KL_41745(Km1,A,Km2,Vmax,n,Vmax_Km)=(NaN)! lambda(Km1, A, Km2, Vmax, n, Vmax_Km, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(Km1, A, Km2, Vmax, n, Vmax_Km, NaN) ! FunctionDefinition id = KL_41746 !KL_41746(Vmax_Km,S,Vmax,Km,A)=(Vmax*S/(Km+S))! lambda(Vmax_Km, S, Vmax, Km, A, Vmax*S/(Km+S)) ! FunctionDefinition id = KL_41747 !KL_41747(A,Vmax_Km,Vmax,Km,S)=(Vmax*S/(Km+S))! lambda(A, Vmax_Km, Vmax, Km, S, Vmax*S/(Km+S)) ! FunctionDefinition id = KL_41748 !KL_41748(Km,S,Vmax_Km,A,Vmax)=(Vmax*S/(Km+S))! lambda(Km, S, Vmax_Km, A, Vmax, Vmax*S/(Km+S)) ! FunctionDefinition id = KL_41758 !KL_41758(S,A,Ki)=(NaN)! lambda(S, A, Ki, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(S, A, Ki, NaN) ! FunctionDefinition id = KL_41759 !KL_41759(S,Ki,A)=(NaN)! lambda(S, Ki, A, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(S, Ki, A, NaN) ! FunctionDefinition id = KL_41766 !KL_41766(A,S,Ki)=(NaN)! lambda(A, S, Ki, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(A, S, Ki, NaN) ! FunctionDefinition id = KL_41765 !KL_41765(Ki,S,A)=(NaN)! lambda(Ki, S, A, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(Ki, S, A, NaN) ! FunctionDefinition id = KL_41764 !KL_41764(S,A,Ki)=(NaN)! lambda(S, A, Ki, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(S, A, Ki, NaN) ! FunctionDefinition id = KL_41763 !KL_41763(Ki,A,S)=(NaN)! lambda(Ki, A, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(Ki, A, S, NaN) ! FunctionDefinition id = KL_41762 !KL_41762(Ki,A,S)=(NaN)! lambda(Ki, A, S, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(Ki, A, S, NaN) ! FunctionDefinition id = KL_41760 !KL_41760(S,A,Ki)=(NaN)! lambda(S, A, Ki, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(S, A, Ki, NaN) ! FunctionDefinition id = KL_41761 !KL_41761(S,A,Ki)=(NaN)! lambda(S, A, Ki, NaN)! the operator NaN is not supported by apm ! the formula is : (NaN) !FunctionDef: lambda(S, A, Ki, NaN) ! FunctionDefinition id = KL_39577 !KL_39577(S,Km,Vmax)=(Vmax*S/(Km+S))! lambda(S, Km, Vmax, Vmax*S/(Km+S)) ! FunctionDefinition id = KL_39576 !KL_39576(Vmax,S,Km)=(Vmax*S/(Km+S))! lambda(Vmax, S, Km, Vmax*S/(Km+S)) ! Compartments ! compart_c=NaN! Compartment: id = compart_cytosol, name = cytosol, constant ! compart_m=NaN! Compartment: id = compart_membrane, name = membrane, constant ! compart_1=NaN! Compartment: id = compart_Cell, name = Cell, constant ! compart_l=NaN! Compartment: id = compart_lysosome, name = lysosome, constant ! compart_2=NaN! Compartment: id = compart_mitochondrion, name = mitochondrion, constant ! End Compartments Parameters End Parameters Variables SPC_2122_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_2122_cytosol, name = Phosphatidylinositol; Compartment:compart_cytosol, affected by kineticLaw SPC_40_cy=1.0 !Is not affected by rule or reaction ! Species: id = SPC_40_cytosol, name = H2O; Compartment:compart_cytosol, affected by kineticLaw SPC_5013_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_5013_cytosol, name = Diacylglycerol; Compartment:compart_cytosol, affected by kineticLaw SPC_5422_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_5422_cytosol, name = 1D-myo-Inositol 1-phosphate; Compartment:compart_cytosol, affected by kineticLaw ENZ_22557=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_225573_cytosol, name = phosphoinositide phospholipase C(Enzyme) wildtype; Compartment:compart_cytosol ! Warning species is not changed by either rules or reactions SPC_212_1=1.0 !Is not affected by rule or reaction ! Species: id = SPC_2122_membrane, name = Phosphatidylinositol; Compartment:compart_membrane, affected by kineticLaw SPC_40_me=1.0 !Is not affected by rule or reaction ! Species: id = SPC_40_membrane, name = H2O; Compartment:compart_membrane, affected by kineticLaw SPC_501_1=1.0 !Is not affected by rule or reaction ! Species: id = SPC_5013_membrane, name = Diacylglycerol; Compartment:compart_membrane, affected by kineticLaw SPC_542_1=1.0 !Is not affected by rule or reaction ! Species: id = SPC_5422_membrane, name = 1D-myo-Inositol 1-phosphate; Compartment:compart_membrane, affected by kineticLaw ENZ_22556=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_225568_membrane, name = phosphoinositide phospholipase C(Enzyme) wildtype; Compartment:compart_membrane ! Warning species is not changed by either rules or reactions SPC_40_Ce=1.0 !Is not affected by rule or reaction ! Species: id = SPC_40_Cell, name = H2O; Compartment:compart_Cell, affected by kineticLaw SPC_23010=1.0 !Is not affected by rule or reaction ! Species: id = SPC_23010_Cell, name = 4-Methylumbelliferyl-beta-N-acetylglucosaminide; Compartment:compart_Cell, affected by kineticLaw SPC_6916_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_6916_Cell, name = N-Acetyl-beta-D-glucosamine; Compartment:compart_Cell, affected by kineticLaw SPC_6439_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_6439_Cell, name = 4-Methylumbelliferone; Compartment:compart_Cell, affected by kineticLaw SPC_5060_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_5060_Cell, name = Heparin; Compartment:compart_Cell ! Warning species is not changed by either rules or reactions ENZ_27384=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_273848_Cell, name = beta-N-acetylhexosaminidase(Enzyme) wildtype isoform A; Compartment:compart_Cell ! Warning species is not changed by either rules or reactions ENZ_27385=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_273854_Cell, name = beta-N-acetylhexosaminidase(Enzyme) wildtype isoform B; Compartment:compart_Cell ! Warning species is not changed by either rules or reactions ENZ_27383=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_273837_Cell, name = beta-N-acetylhexosaminidase(Enzyme) wildtype isoform A; Compartment:compart_Cell ! Warning species is not changed by either rules or reactions ENZ_273_1=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_273842_Cell, name = beta-N-acetylhexosaminidase(Enzyme) wildtype isoform B; Compartment:compart_Cell ! Warning species is not changed by either rules or reactions SPC_21081=1.0 !Is not affected by rule or reaction ! Species: id = SPC_21081_lysosome, name = N-Dodecanoylsphingosine; Compartment:compart_lysosome, affected by kineticLaw SPC_40_ly=1.0 !Is not affected by rule or reaction ! Species: id = SPC_40_lysosome, name = H2O; Compartment:compart_lysosome, affected by kineticLaw SPC_5042_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_5042_lysosome, name = Sphingosine; Compartment:compart_lysosome, affected by kineticLaw SPC_2488_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_2488_lysosome, name = Dodecanoate; Compartment:compart_lysosome, affected by kineticLaw ENZ_11238=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_112389_lysosome, name = ceramidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions SPC_25141=1.0 !Is not affected by rule or reaction ! Species: id = SPC_25141_lysosome, name = N-Oleoyl-D-sphingosine; Compartment:compart_lysosome, affected by kineticLaw SPC_2139_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_2139_lysosome, name = Oleate; Compartment:compart_lysosome, affected by kineticLaw ENZ_11241=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_112419_lysosome, name = ceramidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions SPC_25149=1.0 !Is not affected by rule or reaction ! Species: id = SPC_25149_lysosome, name = N-Hexanoyl-D-erythro-sphingosine; Compartment:compart_lysosome, affected by kineticLaw SPC_2297_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_2297_lysosome, name = Hexanoate; Compartment:compart_lysosome, affected by kineticLaw ENZ_11240=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_112404_lysosome, name = ceramidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions SPC_25159=1.0 !Is not affected by rule or reaction ! Species: id = SPC_25159_lysosome, name = N-Palmitoylsphinganine; Compartment:compart_lysosome, affected by kineticLaw SPC_1990_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1990_lysosome, name = Palmitate; Compartment:compart_lysosome, affected by kineticLaw SPC_5264_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_5264_lysosome, name = Sphinganine; Compartment:compart_lysosome, affected by kineticLaw ENZ_11242=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_112429_lysosome, name = ceramidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions ENZ_11239=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_112394_lysosome, name = ceramidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions SPC_25150=1.0 !Is not affected by rule or reaction ! Species: id = SPC_25150_lysosome, name = N-Octanoyl-D-sphingosine; Compartment:compart_lysosome, affected by kineticLaw SPC_2889_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_2889_lysosome, name = Octanoate; Compartment:compart_lysosome, affected by kineticLaw ENZ_112_1=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_112409_lysosome, name = ceramidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions SPC_25148=1.0 !Is not affected by rule or reaction ! Species: id = SPC_25148_lysosome, name = N-Acetyl-D-sphingosine; Compartment:compart_lysosome, affected by kineticLaw SPC_1278_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1278_lysosome, name = Acetate; Compartment:compart_lysosome, affected by kineticLaw ENZ_112_2=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_112399_lysosome, name = ceramidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions SPC_25151=1.0 !Is not affected by rule or reaction ! Species: id = SPC_25151_lysosome, name = N-Stearoyl-D-sphingosine; Compartment:compart_lysosome, affected by kineticLaw SPC_20032=1.0 !Is not affected by rule or reaction ! Species: id = SPC_20032_lysosome, name = Stearate; Compartment:compart_lysosome, affected by kineticLaw ENZ_112_3=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_112414_lysosome, name = ceramidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions SPC_25130=1.0 !Is not affected by rule or reaction ! Species: id = SPC_25130_lysosome, name = N-Octanoylsphinganine; Compartment:compart_lysosome, affected by kineticLaw ENZ_112_4=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_112424_lysosome, name = ceramidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions SPC_28371=1.0 !Is not affected by rule or reaction ! Species: id = SPC_28371_lysosome, name = 4-Methylumbelliferyl-alpha-D-galactoside; Compartment:compart_lysosome, affected by kineticLaw SPC_90_ly=1.0 !Is not affected by rule or reaction ! Species: id = SPC_90_lysosome, name = alpha-D-Galactose; Compartment:compart_lysosome, affected by kineticLaw SPC_643_1=1.0 !Is not affected by rule or reaction ! Species: id = SPC_6439_lysosome, name = 4-Methylumbelliferone; Compartment:compart_lysosome, affected by kineticLaw ENZ_28685=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_286858_lysosome, name = alpha-galactosidase(Enzyme) wildtype; Compartment:compart_lysosome ! Warning species is not changed by either rules or reactions SPC_1315_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1315_mitochondrion, name = Thymidine; Compartment:compart_mitochondrion, affected by kineticLaw SPC_34_mi=1.0 !Is not affected by rule or reaction ! Species: id = SPC_34_mitochondrion, name = ATP; Compartment:compart_mitochondrion, affected by kineticLaw SPC_65_mi=1.0 !Is not affected by rule or reaction ! Species: id = SPC_65_mitochondrion, name = dTMP; Compartment:compart_mitochondrion, affected by kineticLaw SPC_35_mi=1.0 !Is not affected by rule or reaction ! Species: id = SPC_35_mitochondrion, name = ADP; Compartment:compart_mitochondrion, affected by kineticLaw SPC_27857=1.0 !Is not affected by rule or reaction ! Species: id = SPC_27857_mitochondrion, name = 2',3'-Didehydro-2',3'-dideoxythymidine; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23617=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236178_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_13796=1.0 !Is not affected by rule or reaction ! Species: id = SPC_13796_mitochondrion, name = 5-Fluorodeoxyuridine; Compartment:compart_mitochondrion, affected by kineticLaw ENZ_23618=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236184_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_27854=1.0 !Is not affected by rule or reaction ! Species: id = SPC_27854_mitochondrion, name = 3'-Azido-2',3'-dideoxythymidine; Compartment:compart_mitochondrion, affected by kineticLaw ENZ_23616=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236166_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_27856=1.0 !Is not affected by rule or reaction ! Species: id = SPC_27856_mitochondrion, name = 3'-Fluoro-2',3'-dideoxythymidine; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_236_1=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236172_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23614=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236145_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_2178_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_2178_mitochondrion, name = 2'-Deoxycytidine; Compartment:compart_mitochondrion, affected by kineticLaw SPC_63_mi=1.0 !Is not affected by rule or reaction ! Species: id = SPC_63_mitochondrion, name = dCMP; Compartment:compart_mitochondrion, affected by kineticLaw ENZ_23615=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236155_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_1286_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1286_mitochondrion, name = CTP; Compartment:compart_mitochondrion, affected by kineticLaw SPC_1302_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1302_mitochondrion, name = CDP; Compartment:compart_mitochondrion, affected by kineticLaw ENZ_236_2=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236150_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_27853=1.0 !Is not affected by rule or reaction ! Species: id = SPC_27853_mitochondrion, name = 3'-Azido-2',3'-dideoxythymidine 5'-phosphate; Compartment:compart_mitochondrion, affected by kineticLaw ENZ_236_3=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236140_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_236_4=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236160_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_1678_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1678_mitochondrion, name = dCTP; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23625=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236250_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_1679_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1679_mitochondrion, name = dTTP; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23624=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236244_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23612=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236120_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_236_5=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236125_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_2074_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_2074_mitochondrion, name = 2'-Deoxyuridine; Compartment:compart_mitochondrion, affected by kineticLaw SPC_1334_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1334_mitochondrion, name = dUMP; Compartment:compart_mitochondrion, affected by kineticLaw ENZ_23613=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236130_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_27852=1.0 !Is not affected by rule or reaction ! Species: id = SPC_27852_mitochondrion, name = 5-Fluorodeoxyuridine 5'-phosphate; Compartment:compart_mitochondrion, affected by kineticLaw ENZ_236_6=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236135_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23619=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236190_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_236_7=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236196_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23623=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236238_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_236_8=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236232_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23622=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236226_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_236_9=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236220_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23621=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236214_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23620=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236202_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions ENZ_23_10=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_236208_mitochondrion, name = thymidine kinase(Enzyme) wildtype; Compartment:compart_mitochondrion ! Warning species is not changed by either rules or reactions SPC_5404_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_5404_Cell, name = S-Adenosylmethioninamine; Compartment:compart_Cell, affected by kineticLaw SPC_1941_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1941_Cell, name = Putrescine; Compartment:compart_Cell, affected by kineticLaw SPC_3088_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_3088_Cell, name = Spermidine; Compartment:compart_Cell, affected by kineticLaw SPC_1960_=1.0 !Is not affected by rule or reaction ! Species: id = SPC_1960_Cell, name = 5'-Deoxy-5'-(methylthio)adenosine; Compartment:compart_Cell, affected by kineticLaw ENZ_22404=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_224044_Cell, name = spermidine synthase(Enzyme) wildtype; Compartment:compart_Cell ! Warning species is not changed by either rules or reactions ENZ_22403=1.0 !Is not affected by rule or reaction ! Species: id = ENZ_224039_Cell, name = spermidine synthase(Enzyme) wildtype; Compartment:compart_Cell ! Warning species is not changed by either rules or reactions End Variables Intermediates REAC_0=KL_39851(Km_SPC_21) ! Reaction: id = REAC_0 REAC_1=KL_39850(Km_SPC__1) ! Reaction: id = REAC_1 REAC_2=KL_48160(SPC_23010, IC_50_SPC) ! Reaction: id = REAC_2 REAC_3=KL_48161(IC_50_S_1, SPC_23010) ! Reaction: id = REAC_3 REAC_4=KL_48158(Km_SPC_23, Vmax, SPC_23010) ! Reaction: id = REAC_4 REAC_5=KL_48159(Km_SPC__2, Vmax_1, SPC_23010) ! Reaction: id = REAC_5 REAC_6=KL_21313(Km_SPC__3, SPC_21081, Vmax_1_2) ! Reaction: id = REAC_6 REAC_7=KL_21319(SPC_25141, EA) ! Reaction: id = REAC_7 REAC_8=KL_21316(SPC_25149, EA_1) ! Reaction: id = REAC_8 REAC_9=KL_21321(EA_1_2, SPC_25159) ! Reaction: id = REAC_9 REAC_10=KL_21314(SPC_21081, EA_1_2_3) ! Reaction: id = REAC_10 REAC_11=KL_21317(EA_1_2__4, SPC_25150) ! Reaction: id = REAC_11 REAC_12=KL_21315(EA_1_2__5, SPC_25148) ! Reaction: id = REAC_12 REAC_13=KL_21318(EA_1_2__6, SPC_25151) ! Reaction: id = REAC_13 REAC_14=KL_21320(EA_1_2__7, SPC_25130) ! Reaction: id = REAC_14 REAC_15=KL_50493(Vmax_1__3, SPC_28371, Km_SPC_28) ! Reaction: id = REAC_15 REAC_16=KL_41756(Ki_SPC_27, SPC_34_mi, SPC_1315_) ! Reaction: id = REAC_16 REAC_17=KL_41757(Ki_SPC_13, SPC_34_mi, SPC_1315_) ! Reaction: id = REAC_17 REAC_18=KL_41754(SPC_1315_, SPC_34_mi, Ki_SPC__1) ! Reaction: id = REAC_18 REAC_19=KL_41755(SPC_34_mi, Ki_SPC__2, SPC_1315_) ! Reaction: id = REAC_19 REAC_20=KL_41750(Km_SPC_34, SPC_1315_, Vmax_1__4, SPC_34_mi) ! Reaction: id = REAC_20 REAC_21=KL_41752(SPC_34_mi, SPC_2178_, Km_SPC__4, Vmax_1__5) ! Reaction: id = REAC_21 REAC_22=KL_41751(SPC_1286_, Vmax_1__6, Km_SPC_12, SPC_1315_) ! Reaction: id = REAC_22 REAC_23=KL_41749(n_SPC_278, Vmax_Km_S, Km2_SPC_2, Km1_SPC_2, SPC_34_mi, Vmax_1__7) ! Reaction: id = REAC_23 REAC_24=KL_41753(SPC_1286_, Vmax_1__8, Km_SPC__5, SPC_2178_) ! Reaction: id = REAC_24 REAC_25=KL_41768(SPC_1678_, Ki_SPC_16, SPC_1315_, n_SPC_167, SPC_34_mi) ! Reaction: id = REAC_25 REAC_26=KL_41767(Ki_SPC__3, SPC_1315_, SPC_34_mi) ! Reaction: id = REAC_26 REAC_27=KL_41745(Km1_SPC_1, SPC_34_mi, Km2_SPC_1, Vmax_1__9, n_SPC_131, Vmax_Km_1) ! Reaction: id = REAC_27 REAC_28=KL_41746(Vmax_Km_2, SPC_2178_, Vmax_1_10, Km_SPC__6, SPC_34_mi) ! Reaction: id = REAC_28 REAC_29=KL_41747(SPC_34_mi, Vmax_Km_3, Vmax_1_11, Km_SPC_20, SPC_2074_) ! Reaction: id = REAC_29 REAC_30=KL_41748(Km_SPC_13, SPC_13796, Vmax_Km_4, SPC_34_mi, Vmax_1_12) ! Reaction: id = REAC_30 REAC_31=KL_41758(SPC_1315_, SPC_34_mi, Ki_SPC_20) ! Reaction: id = REAC_31 REAC_32=KL_41759(SPC_1315_, Ki_SPC_21, SPC_34_mi) ! Reaction: id = REAC_32 REAC_33=KL_41766(SPC_34_mi, SPC_2178_, Ki_SPC__4) ! Reaction: id = REAC_33 REAC_34=KL_41765(Ki_SPC__5, SPC_2178_, SPC_34_mi) ! Reaction: id = REAC_34 REAC_35=KL_41764(SPC_2178_, SPC_34_mi, Ki_SPC__6) ! Reaction: id = REAC_35 REAC_36=KL_41763(Ki_SPC__7, SPC_34_mi, SPC_2074_) ! Reaction: id = REAC_36 REAC_37=KL_41762(Ki_SPC__8, SPC_34_mi, SPC_2074_) ! Reaction: id = REAC_37 REAC_38=KL_41760(SPC_2074_, SPC_34_mi, Ki_SPC__9) ! Reaction: id = REAC_38 REAC_39=KL_41761(SPC_2074_, SPC_34_mi, Ki_SPC_10) ! Reaction: id = REAC_39 REAC_40=KL_39577(SPC_5404_, Km_SPC_54, Vmax_1_13) ! Reaction: id = REAC_40 REAC_41=KL_39576(Vmax_1_14, SPC_1941_, Km_SPC_19) ! Reaction: id = REAC_41 End Intermediates Equations $SPC_2122_=(1/(compart_c))*((-1.0 * REAC_0)) $SPC_40_cy=(1/(compart_c))*((-1.0 * REAC_0)) $SPC_5013_=(1/(compart_c))*(( 1.0 * REAC_0)) $SPC_5422_=(1/(compart_c))*(( 1.0 * REAC_0)) $SPC_212_1=(1/(compart_m))*((-1.0 * REAC_1)) $SPC_40_me=(1/(compart_m))*((-1.0 * REAC_1)) $SPC_501_1=(1/(compart_m))*(( 1.0 * REAC_1)) $SPC_542_1=(1/(compart_m))*(( 1.0 * REAC_1)) $SPC_40_Ce=(1/(compart_1))*((-1.0 * REAC_2) + (-1.0 * REAC_3) + (-1.0 * REAC_4) + (-1.0 * REAC_5)) $SPC_23010=(1/(compart_1))*((-1.0 * REAC_2) + (-1.0 * REAC_3) + (-1.0 * REAC_4) + (-1.0 * REAC_5)) $SPC_6916_=(1/(compart_1))*(( 1.0 * REAC_2) + ( 1.0 * REAC_3) + ( 1.0 * REAC_4) + ( 1.0 * REAC_5)) $SPC_6439_=(1/(compart_1))*(( 1.0 * REAC_2) + ( 1.0 * REAC_3) + ( 1.0 * REAC_4) + ( 1.0 * REAC_5)) $SPC_21081=(1/(compart_l))*((-1.0 * REAC_6) + (-1.0 * REAC_10)) $SPC_40_ly=(1/(compart_l))*((-1.0 * REAC_6) + (-1.0 * REAC_7) + (-1.0 * REAC_8) + (-1.0 * REAC_9) + (-1.0 * REAC_10) + (-1.0 * REAC_11) + (-1.0 * REAC_12) + (-1.0 * REAC_13) + (-1.0 * REAC_14) + (-1.0 * REAC_15)) $SPC_5042_=(1/(compart_l))*(( 1.0 * REAC_6) + ( 1.0 * REAC_7) + ( 1.0 * REAC_8) + ( 1.0 * REAC_10) + ( 1.0 * REAC_11) + ( 1.0 * REAC_12) + ( 1.0 * REAC_13)) $SPC_2488_=(1/(compart_l))*(( 1.0 * REAC_6) + ( 1.0 * REAC_10)) $SPC_25141=(1/(compart_l))*((-1.0 * REAC_7)) $SPC_2139_=(1/(compart_l))*(( 1.0 * REAC_7)) $SPC_25149=(1/(compart_l))*((-1.0 * REAC_8)) $SPC_2297_=(1/(compart_l))*(( 1.0 * REAC_8)) $SPC_25159=(1/(compart_l))*((-1.0 * REAC_9)) $SPC_1990_=(1/(compart_l))*(( 1.0 * REAC_9)) $SPC_5264_=(1/(compart_l))*(( 1.0 * REAC_9) + ( 1.0 * REAC_14)) $SPC_25150=(1/(compart_l))*((-1.0 * REAC_11)) $SPC_2889_=(1/(compart_l))*(( 1.0 * REAC_11) + ( 1.0 * REAC_14)) $SPC_25148=(1/(compart_l))*((-1.0 * REAC_12)) $SPC_1278_=(1/(compart_l))*(( 1.0 * REAC_12)) $SPC_25151=(1/(compart_l))*((-1.0 * REAC_13)) $SPC_20032=(1/(compart_l))*(( 1.0 * REAC_13)) $SPC_25130=(1/(compart_l))*((-1.0 * REAC_14)) $SPC_28371=(1/(compart_l))*((-1.0 * REAC_15)) $SPC_90_ly=(1/(compart_l))*(( 1.0 * REAC_15)) $SPC_643_1=(1/(compart_l))*(( 1.0 * REAC_15)) $SPC_1315_=(1/(compart_2))*((-1.0 * REAC_16) + (-1.0 * REAC_17) + (-1.0 * REAC_18) + (-1.0 * REAC_19) + (-1.0 * REAC_20) + (-1.0 * REAC_22) + (-1.0 * REAC_25) + (-1.0 * REAC_26) + (-1.0 * REAC_27) + (-1.0 * REAC_31) + (-1.0 * REAC_32)) $SPC_34_mi=(1/(compart_2))*((-1.0 * REAC_16) + (-1.0 * REAC_17) + (-1.0 * REAC_18) + (-1.0 * REAC_19) + (-1.0 * REAC_20) + (-1.0 * REAC_21) + (-1.0 * REAC_23) + (-1.0 * REAC_25) + (-1.0 * REAC_26) + (-1.0 * REAC_27) + (-1.0 * REAC_28) + (-1.0 * REAC_29) + (-1.0 * REAC_30) + (-1.0 * REAC_31) + (-1.0 * REAC_32) + (-1.0 * REAC_33) + (-1.0 * REAC_34) + (-1.0 * REAC_35) + (-1.0 * REAC_36) + (-1.0 * REAC_37) + (-1.0 * REAC_38) + (-1.0 * REAC_39)) $SPC_65_mi=(1/(compart_2))*(( 1.0 * REAC_16) + ( 1.0 * REAC_17) + ( 1.0 * REAC_18) + ( 1.0 * REAC_19) + ( 1.0 * REAC_20) + ( 1.0 * REAC_22) + ( 1.0 * REAC_25) + ( 1.0 * REAC_26) + ( 1.0 * REAC_27) + ( 1.0 * REAC_31) + ( 1.0 * REAC_32)) $SPC_35_mi=(1/(compart_2))*(( 1.0 * REAC_16) + ( 1.0 * REAC_17) + ( 1.0 * REAC_18) + ( 1.0 * REAC_19) + ( 1.0 * REAC_20) + ( 1.0 * REAC_21) + ( 1.0 * REAC_23) + ( 1.0 * REAC_25) + ( 1.0 * REAC_26) + ( 1.0 * REAC_27) + ( 1.0 * REAC_28) + ( 1.0 * REAC_29) + ( 1.0 * REAC_30) + ( 1.0 * REAC_31) + ( 1.0 * REAC_32) + ( 1.0 * REAC_33) + ( 1.0 * REAC_34) + ( 1.0 * REAC_35) + ( 1.0 * REAC_36) + ( 1.0 * REAC_37) + ( 1.0 * REAC_38) + ( 1.0 * REAC_39)) $SPC_13796=(1/(compart_2))*((-1.0 * REAC_30)) $SPC_27854=(1/(compart_2))*((-1.0 * REAC_23)) $SPC_2178_=(1/(compart_2))*((-1.0 * REAC_21) + (-1.0 * REAC_24) + (-1.0 * REAC_28) + (-1.0 * REAC_33) + (-1.0 * REAC_34) + (-1.0 * REAC_35)) $SPC_63_mi=(1/(compart_2))*(( 1.0 * REAC_21) + ( 1.0 * REAC_24) + ( 1.0 * REAC_28) + ( 1.0 * REAC_33) + ( 1.0 * REAC_34) + ( 1.0 * REAC_35)) $SPC_1286_=(1/(compart_2))*((-1.0 * REAC_22) + (-1.0 * REAC_24)) $SPC_1302_=(1/(compart_2))*(( 1.0 * REAC_22) + ( 1.0 * REAC_24)) $SPC_27853=(1/(compart_2))*(( 1.0 * REAC_23)) $SPC_2074_=(1/(compart_2))*((-1.0 * REAC_29) + (-1.0 * REAC_36) + (-1.0 * REAC_37) + (-1.0 * REAC_38) + (-1.0 * REAC_39)) $SPC_1334_=(1/(compart_2))*(( 1.0 * REAC_29) + ( 1.0 * REAC_36) + ( 1.0 * REAC_37) + ( 1.0 * REAC_38) + ( 1.0 * REAC_39)) $SPC_27852=(1/(compart_2))*(( 1.0 * REAC_30)) $SPC_5404_=(1/(compart_1))*((-1.0 * REAC_40) + (-1.0 * REAC_41)) $SPC_1941_=(1/(compart_1))*((-1.0 * REAC_40) + (-1.0 * REAC_41)) $SPC_3088_=(1/(compart_1))*(( 1.0 * REAC_40) + ( 1.0 * REAC_41)) $SPC_1960_=(1/(compart_1))*(( 1.0 * REAC_40) + ( 1.0 * REAC_41)) End Equations End Model !Parameter Count:0 !Variable Count:98 !Intermediate Count:42 !Equation Count:98